Toxicology in the 21st Century

Infrastructure Teams

 

Points of Contact

David Reif Ph.D.
NIH | National Institute of Health
Russell Thomas Ph.D.
EPA | U.S. Environment Protection Agency
Suzanne Fitzpatrick Ph.D.
FDA | U.S. Food and Drug Administration
Anton Simeonov Ph.D.
NCATS | National Center for Advancing Translational Sciences

Assay Evaluation and Screening

  • Identify toxicity pathways & corresponding assays
  • Review nominated assays
  • Prioritize assays for qHTS
Co-Chairs
Menghang Xia Ph.D.
NCATS | National Center for Advancing Translational Sciences
Kristine Witt M.S.
NTP | National Toxicology Program
Michael Santillo Ph.D.
FDA | U.S. Food and Drug Administration
Steve Simmons Research Toxicologist
EPA | U.S. Environment Protection Agency

Chemical Selection

  • Establish compound libraries for qHTS (10K, mixtures, water-soluble)
  • Establish library QC procedures for identity, purity, concentration, and stability
Co-Chairs
Ruili Huang Ph.D.
NCATS | National Center for Advancing Translational Sciences
Suramya Waidyanatha Ph.D.
NTP | National Toxicology Program
Donna Mendrick Ph.D.
FDA | U.S. Food and Drug Administration
Katherine Coutros Ph.D.
EPA | U.S. Environmental Protection Agency

Communications Team

  • Provide both external and internal communications support for the Tox21 program
Co-Chairs
Monica Linnenbrink M.P.A.
EPA | U.S. Environment Protection Agency
Anna Rossoshek M.S., M.B.A.
NCATS | National Center for Advancing Translational Sciences
Sebastian Cianci  
FDA | U.S. Food and Drug Administration