NCATS | National Center for Advancing Translational Sciences
Assay Evaluation and Screening
Identify toxicity pathways & corresponding assays
Review nominated assays
Prioritize assays for qHTS
Co-Chairs
Menghang XiaPh.D.
NCATS | National Center for Advancing Translational Sciences
Kristine WittM.S.
NTP | National Toxicology Program
Michael SantilloPh.D.
FDA | U.S. Food and Drug Administration
Steve SimmonsResearch Toxicologist
EPA | U.S. Environment Protection Agency
Chemical Selection
Establish compound libraries for qHTS (10K, mixtures, water-soluble)
Establish library QC procedures for identity, purity, concentration, and stability
Co-Chairs
Ruili HuangPh.D.
NCATS | National Center for Advancing Translational Sciences
Suramya WaidyanathaPh.D.
NTP | National Toxicology Program
Donna MendrickPh.D.
FDA | U.S. Food and Drug Administration
Katherine CoutrosPh.D.
EPA | U.S. Environmental Protection Agency
Communications Team
Provide both external and internal communications support for the Tox21 program
Co-Chairs
Monica LinnenbrinkM.P.A.
EPA | U.S. Environment Protection Agency
Anna RossoshekM.S., M.B.A.
NCATS | National Center for Advancing Translational Sciences
Sebastian Cianci
FDA | U.S. Food and Drug Administration
Program Highlights
NIEHS/NTP Welcomes David Reif to Tox21 family
David Reif, Ph.D., joined the NIEHS Division of Translational Toxicology in October 2022. As the lead for the Predictive Toxicology Branch, Reif oversees key partnerships such as the…
First Meeting of the Committee on Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for Use in Human Health Risk Assessment
The National Academies of Sciences, Engineering, and Medicine is undertaking a study to provide the Environmental Protection Agency (EPA) with a review of the variability and relevance of…
Tox21 Assay Recognized in Society for Laboratory Automation and Screening (SLAS) Top Ten List
For their work developing a new assay to identify molecules that block angiogenesis in special screening plates Tox 21 collaborators were awarded with a spot on the 2018…
Tox21 Scientists Teach Continuing Education Courses at the Society of Toxicology’s Annual Conference
As part of their participation in the Annual Society of Toxicology (SOT) conference, Tox21 collaborators participated in SOT’s Continuing Education program. SOT offers a wide range of courses…
Tox21 Scientists Prioritize Compounds to Advance Research on Mitochondrial Damage
As part of the Tox21 collaboration, scientists developed of an analytical approach to enable researchers to prioritize environmental chemicals for their ability to disrupt mitochondria, the power generators of…